Heavy-chain receptor editing unbound

Heavy-chain receptor editing unbound.

With all of the certainty of death and taxes, questions regarding the mechanisms of immunological tolerance remain fixtures across the landscape of immunology. From Paul Ehlirch’s “horror autotoxicus” (reviewed in ref. 1) to the current synthesis of tolerance by apoptosis, anergy, and receptor editing (2), the mechanisms of immunological tolerance remain, despite substantial research effort, en...

Molecular mechanisms involved in receptor editing at the Ig heavy chain locus.

In receptor editing, a phenomenon that has recently come to light and into favor, a rearranged VDJ or VJ gene segment encoding a variable region of an Ig chain is replaced by another. In this commentary, the molecular mechanisms involved in the editing process are examined in some detail. Editing is most likely mediated by the same V(D)J recombinase activity responsible for the formation of the...

Immunoglobulin kappa chain receptor editing in systemic lupus erythematosus.

To determine whether receptor editing of Vkappa genes was involved in the pathogenesis of systemic lupus erythematosus (SLE), the usage of Vkappa and Jkappa gene elements from individual peripheral CD19(+) B cells obtained from a patient with untreated SLE was examined. No differences in the Vkappa and Jkappa gene usage in the nonproductive gene repertoire of this SLE patient were noted compare...

Ig light chain receptor editing in anergic B cells.

Receptor editing in the bone marrow (BM) serves to modify the Ag receptor specificity of immature self-reactive B cells, while anergy functionally silences self-reactive clones. Here, we demonstrate that anergic B cells in hen egg lysozyme Ig (HEL-Ig)/soluble HEL double transgenic mice show evidence of having undergone receptor editing in vivo, as demonstrated by the presence of elevated levels...

IgM Heavy Chain